Abstract
Streptozotocin-induced diabetes increased sorbitol levels in the rat renal medulla. The activities of renal medullary aldose reductase and sorbitol dehydrogenase, responsible for the formation and metabolism of sorbitol, favor sorbitol formation and did not change in diabetes. The elevated sorbitol concentration appears to be due to an increase in medullary glucose concentration.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aldehyde Reductase / biosynthesis
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Aldehyde Reductase / metabolism
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Animals
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Diabetes Mellitus, Experimental / enzymology
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Diabetes Mellitus, Experimental / metabolism*
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Kidney Cortex / enzymology
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Kidney Cortex / metabolism
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Kidney Medulla / enzymology
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Kidney Medulla / metabolism*
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L-Iditol 2-Dehydrogenase / biosynthesis
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L-Iditol 2-Dehydrogenase / metabolism
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Male
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Rats
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Rats, Inbred Strains
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Sorbitol / biosynthesis*
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Sorbitol / metabolism
Substances
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Sorbitol
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L-Iditol 2-Dehydrogenase
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Aldehyde Reductase