Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112

Meng Bai; Guo-Lei Huang; Rong-Qing Mei; Bin Wang; You-Ping Luo; Xu-Hua Nong; Guang-Ying Chen; Cai-Juan Zheng

doi:10.3390/md17080433

Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112

Mar Drugs. 2019 Jul 24;17(8):433. doi: 10.3390/md17080433.

Authors

Meng Bai^{1

2}, Guo-Lei Huang^{1

2}, Rong-Qing Mei^{1

2}, Bin Wang^{1

2}, You-Ping Luo^{1

2}, Xu-Hua Nong^{1

2}, Guang-Ying Chen^{3

4}, Cai-Juan Zheng^{5

6}

Affiliations

¹ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.
² Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan 571158, China.
³ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China. [email protected].
⁴ Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan 571158, China. [email protected].
⁵ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China. [email protected].
⁶ Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan 571158, China. [email protected].

Abstract

Three new lactones penicilactones A-C (1-3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo₂(OAc)₄-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC₅₀ value of 78.5 (±0.58) μg/mL.

Keywords: Penicillium sp.; antibacterial activity; insecticidal activity; lactones.

MeSH terms

Animals
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Circular Dichroism / methods
Culex / drug effects
Insecticides / chemistry*
Insecticides / pharmacology*
Lactones / chemistry*
Lactones / pharmacology*
Magnetic Resonance Spectroscopy / methods
Microbial Sensitivity Tests / methods
Penicillium / chemistry*
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Insecticides
Lactones