Oxygen Therapy and Pulmonary Hypertension in Preterm Infants

Samuel J Gentle; Steven H Abman; Namasivayam Ambalavanan

doi:10.1016/j.clp.2019.05.009

Oxygen Therapy and Pulmonary Hypertension in Preterm Infants

Clin Perinatol. 2019 Sep;46(3):611-619. doi: 10.1016/j.clp.2019.05.009. Epub 2019 Jun 20.

Authors

Samuel J Gentle¹, Steven H Abman², Namasivayam Ambalavanan³

Affiliations

¹ The University of Alabama at Birmingham, 176F Suite 9390F, Women and Infants Center, 619 South 20th St., Birmingham, AL 35233, USA. Electronic address: [email protected].
² University of Colorado, Children's Hospital Colorado, 13123 E 16th Ave B395, Aurora, CO 80045, USA.
³ The University of Alabama at Birmingham, 176F Suite 9390F, Women and Infants Center, 619 South 20th St., Birmingham, AL 35233, USA.

PMID: 31345551
DOI: 10.1016/j.clp.2019.05.009

Abstract

The goal of oxygen therapy and oxygen saturation targeting in extremely preterm infants is to improve outcomes and balance the risks associated with both hypoxemia and hyperoxemia. Although the NeOProM trials addressed whether low or high oxygen saturation targets affect the most important outcomes of extreme prematurity including death and other co-morbidities, the trials did not evaluate infants for pulmonary hypertension. There is limited evidence for the optimal oxygen saturation targets in extremely preterm infants that can be used to prevent the development of pulmonary hypertension and manage pulmonary hypertension once developed.

Keywords: Bronchopulmonary dysplasia; Bronchopulmonary-associated pulmonary hypertension; Extremely premature; Infant; Infant mortality; Oxygen.

Publication types

Review

MeSH terms

Humans
Hypertension, Pulmonary / therapy*
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / therapy*
Oxygen Inhalation Therapy / methods*