Venetoclax in CLL patients who progress after B-cell Receptor inhibitor treatment: a retrospective multi-centre Italian experience

Idanna Innocenti; Francesca Morelli; Francesco Autore; Alfonso Piciocchi; Annamaria Frustaci; Francesca R Mauro; Luana Schiattone; Livio Trentin; Giovanni Del Poeta; Gianluigi Reda; Gian M Rigolin; Adalberto Ibatici; Stefania Ciolli; Marta Coscia; Paolo Sportoletti; Roberta Murru; Luciano Levato; Massimo Gentile; Giovanni D'Arena; Dimitar G Efremov; Alessandra Tedeschi; Lydia Scarfò; Antonio Cuneo; Robin Foà; Luca Laurenti

doi:10.1111/bjh.16123

Venetoclax in CLL patients who progress after B-cell Receptor inhibitor treatment: a retrospective multi-centre Italian experience

Br J Haematol. 2019 Oct;187(1):e8-e11. doi: 10.1111/bjh.16123. Epub 2019 Jul 31.

Authors

Idanna Innocenti¹, Francesca Morelli², Francesco Autore¹, Alfonso Piciocchi³, Annamaria Frustaci⁴, Francesca R Mauro⁵, Luana Schiattone⁶, Livio Trentin⁷, Giovanni Del Poeta⁸, Gianluigi Reda⁹, Gian M Rigolin¹⁰, Adalberto Ibatici¹¹, Stefania Ciolli¹², Marta Coscia¹³, Paolo Sportoletti¹⁴, Roberta Murru¹⁵, Luciano Levato¹⁶, Massimo Gentile¹⁷, Giovanni D'Arena¹⁸, Dimitar G Efremov¹⁹, Alessandra Tedeschi⁴, Lydia Scarfò⁶, Antonio Cuneo¹⁰, Robin Foà⁵, Luca Laurenti^{1

2}

Affiliations

¹ Institute of Haematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
² Institute of Haematology, Università Cattolica del Sacro Cuore, Roma, Italy.
³ Italian Group for Adult Haematological Diseases (GIMEMA), Data Centre, Roma, Italy.
⁴ Haematology, Niguarda Cancer Centre, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
⁵ Haematology, Department of Translational and Precision Medicine, Sapienza University, Roma, Italy.
⁶ Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele and Università Vita-Salute San Raffaele, Milano, Italy.
⁷ Haematology and Clinical Immunology, Department of Medicine, Padova, Italy.
⁸ Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Roma, Italy.
⁹ IRCCS Ca' Granda - Università degli Studi, Milano, Italy.
¹⁰ Haematology section - University of Ferrara, Ferrara, Italy.
¹¹ Division of Haematology and Bone Marrow Transplant, IRCCS San Martino-IST, Genova, Italy.
¹² Haematology Unit, Careggi Hospital, Firenze, Italy.
¹³ Division of Haematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy.
¹⁴ Haematology and Clinical Immunology, University of Perugia, Perugia, Italy.
¹⁵ Haematology and Stem Cell Transplantation Unit, Ospedale Oncologico A. Businco, AO Brotzu, Cagliari, Italy.
¹⁶ Haematology Unit, A. Pugliese Hospital, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy.
¹⁷ Haematology Section, Cosenza Hospital, Cosenza, Italy.
¹⁸ Haematology and Stem cell Transplantation Unit, IRCCSCROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.
¹⁹ Molecular Haematology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.

PMID: 31364153
DOI: 10.1111/bjh.16123

No abstract available

Keywords: B-Cell receptor; chronic lymphocytic leukaemia; ibrutinib; idelalisib; venetoclax.

Publication types

Multicenter Study

MeSH terms

Adenine / analogs & derivatives
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Bridged Bicyclo Compounds, Heterocyclic / administration & dosage
Disease Progression
Drug Administration Schedule
Humans
Kaplan-Meier Estimate
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
Piperidines
Purines / administration & dosage
Pyrazoles / administration & dosage
Pyrimidines / administration & dosage
Quinazolinones / administration & dosage
Receptors, Antigen, B-Cell / antagonists & inhibitors
Retrospective Studies
Sulfonamides / administration & dosage

Substances

Bridged Bicyclo Compounds, Heterocyclic
Piperidines
Purines
Pyrazoles
Pyrimidines
Quinazolinones
Receptors, Antigen, B-Cell
Sulfonamides
ibrutinib
Adenine
venetoclax
idelalisib