Expression of parathyroid hormone-related protein mRNA in tumors obtained from patients with humoral hypercalcemia of malignancy

S Honda; K Yamaguchi; M Suzuki; Y Sato; I Adachi; S Kimura; K Abe

doi:10.1111/j.1349-7006.1988.tb02221.x

Expression of parathyroid hormone-related protein mRNA in tumors obtained from patients with humoral hypercalcemia of malignancy

Jpn J Cancer Res. 1988 Jun;79(6):677-81. doi: 10.1111/j.1349-7006.1988.tb02221.x.

Authors

S Honda¹, K Yamaguchi, M Suzuki, Y Sato, I Adachi, S Kimura, K Abe

Affiliation

¹ Growth Factor Division, National Cancer Center Research Institut, Tokyo.

Abstract

Human parathyroid hormone-related protein (PTHrP) mRNA was detected in all fresh cancer tissues consecutively obtained from 6 patients with humoral hypercalcemia of malignancy (HHM). The primary sites of the cancers in these cases were distributed among different organs including the lung, esophagus, kidney and ovary. PTHrP mRNA was undetectable in all 10 fresh cancer tissues obtained from normocalcemic patients. These results suggest PTHrP as a major cause of HHM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Female
Humans
Hypercalcemia / etiology*
Male
Middle Aged
Neoplasm Proteins / genetics*
Neoplasms / metabolism*
Nucleic Acid Hybridization
Paraneoplastic Syndromes / etiology*
Parathyroid Hormone-Related Protein
RNA, Messenger / analysis*

Substances

Neoplasm Proteins
PTHLH protein, human
Parathyroid Hormone-Related Protein
RNA, Messenger