Computer-automated prediction of the mutagenicity of benzidine, 4,4"-diaminoterphenyl, 4-dimethylaminoazobenzene and 4-cyanodimethylaniline: comparison with the results of the Second UKEMS Collaborative Study

H S Rosenkranz; M R Frierson; G Klopman

doi:10.1093/mutage/1.4.275

Computer-automated prediction of the mutagenicity of benzidine, 4,4"-diaminoterphenyl, 4-dimethylaminoazobenzene and 4-cyanodimethylaniline: comparison with the results of the Second UKEMS Collaborative Study

Mutagenesis. 1986 Jul;1(4):275-82. doi: 10.1093/mutage/1.4.275.

Authors

H S Rosenkranz¹, M R Frierson, G Klopman

Affiliation

¹ Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106.

PMID: 3137412
DOI: 10.1093/mutage/1.4.275

Abstract

There was agreement between the experimental results, obtained in the course of the Second UKEMS Collaborative Study, for the mutagenicity in Salmonella typhimurium of benzidine, 4,4"-diaminoterphenyl, 4-dimethylaminoazobenzene and 4-cyanodimethylaniline and the mutagenicity predicted by CASE (Computer Automated Structure Evaluation), a recently developed artificial intelligence system.

Publication types

Comparative Study
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Aniline Compounds / adverse effects*
Benzidines / adverse effects*
Software*
Terphenyl Compounds / adverse effects*
p-Dimethylaminoazobenzene / adverse effects*

Substances

Aniline Compounds
Benzidines
Terphenyl Compounds
benzidine
4,4''-diaminoterphenyl
4-cyano-N,N-dimethylaniline
p-Dimethylaminoazobenzene