Calcium: A New Guardian of Naive Pluripotency

Yuqing Zhu; Jin Zhang

doi:10.1016/j.stem.2019.07.004

Calcium: A New Guardian of Naive Pluripotency

Cell Stem Cell. 2019 Aug 1;25(2):169-170. doi: 10.1016/j.stem.2019.07.004.

Authors

Yuqing Zhu¹, Jin Zhang²

Affiliations

¹ Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences & Zhejiang University-University of Edinburgh Joint Institute, Zhejiang University School of Medicine, Hangzhou 310058, China.
² Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences & The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: [email protected].

PMID: 31374195
DOI: 10.1016/j.stem.2019.07.004

Abstract

In this issue of Cell Stem Cell, MacDougall et al. (2019) utilized a CRISPR mutagenesis screen to identify factors for mESC self-renewal and found that intracellular calcium and nuclear export act in naive pluripotency exit. Combined knockout of Tcf7l1 and the calcium transporter Atp2b1 enabled mESCs to self-renew in the absence of LIF and 2i.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Active Transport, Cell Nucleus
Calcium*
Cytoplasm
Homeostasis
Mouse Embryonic Stem Cells*

Substances

Calcium