Abstract
The case is reported of a 57-year-old woman with familial amyloidotic polyneuropathy and concomitant orthostatic hypotension for which L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) was clinically effective. Testing of autonomic function under telemetric intra-arterial pressure monitoring before and during L-threo-DOPS treatment clearly demonstrated the pathophysiology of the sympathetic nervous system and its modification by L-threo-DOPS.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amyloidosis / drug therapy*
-
Amyloidosis / genetics
-
Amyloidosis / physiopathology
-
Blood Circulation / drug effects*
-
Blood Pressure / drug effects
-
Consciousness
-
Droxidopa / therapeutic use*
-
Female
-
Heart Rate
-
Humans
-
Hypotension, Orthostatic / complications
-
Hypotension, Orthostatic / drug therapy
-
Hypotension, Orthostatic / physiopathology
-
Middle Aged
-
Nervous System / drug effects*
-
Nervous System / physiopathology
-
Nervous System Diseases / drug therapy*
-
Nervous System Diseases / genetics
-
Nervous System Diseases / physiopathology
-
Serine / analogs & derivatives*