Abstract
Unraveling the principles of cardiac chromatin organization for next generation therapies in heart disease
Keywords:
CCCTC-binding factor; chromatin; epigenomics; heart failure.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta
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CCCTC-Binding Factor / deficiency
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CCCTC-Binding Factor / physiology*
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Cardiovascular Agents / pharmacology*
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Cardiovascular Agents / therapeutic use
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Cardiovascular Diseases / drug therapy*
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Cardiovascular Diseases / genetics
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Cardiovascular Diseases / pathology
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Chromatin / ultrastructure*
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Chromatin Assembly and Disassembly / drug effects
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Constriction
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Disease Models, Animal
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Drug Design
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Enhancer Elements, Genetic
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Epigenesis, Genetic / drug effects
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Humans
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Mice
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Mice, Knockout
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Molecular Targeted Therapy*
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Myocytes, Cardiac / metabolism
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Myocytes, Cardiac / ultrastructure
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Polymorphism, Single Nucleotide
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Transcription, Genetic / drug effects
Substances
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CCCTC-Binding Factor
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CTCF protein, human
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Cardiovascular Agents
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Chromatin
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Ctcf protein, mouse