ZEB2 in T-cells and T-ALL

Stien De Coninck; Geert Berx; Tom Taghon; Pieter Van Vlierberghe; Steven Goossens

doi:10.1016/j.jbior.2019.100639

ZEB2 in T-cells and T-ALL

Adv Biol Regul. 2019 Dec:74:100639. doi: 10.1016/j.jbior.2019.100639. Epub 2019 Jul 27.

Authors

Stien De Coninck¹, Geert Berx², Tom Taghon³, Pieter Van Vlierberghe¹, Steven Goossens⁴

Affiliations

¹ Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
² Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
³ Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.
⁴ Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: [email protected].

PMID: 31383581
DOI: 10.1016/j.jbior.2019.100639

Abstract

The identification of the rare but recurrent t(2; 14)(q22; q32) translocation involving the ZEB2 locus in T-cell acute lymphoblastic leukemia, suggested that ZEB2 is an oncogenic driver of this high-risk subtype of leukemia. ZEB2, a zinc finger E-box homeobox binding transcription factor, is a master regulator of cellular plasticity and its expression is correlated with poor overall survival of cancer patients. Recent loss- and gain-of-function in the mouse revealed important roles of ZEB2 during different stages of hematopoiesis, including the T-cell lineage. Here, we summarize the roles of ZEB2 in T-cells, their development, and malignant transformation to T-ALL.

Keywords: Cancer stem cells; EMT; IL7R; T-cell acute lymphoblastic leukemia; ZEB2.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism*
Cell Transformation, Neoplastic / pathology
Chromosomes, Human, Pair 14 / genetics
Chromosomes, Human, Pair 14 / metabolism
Chromosomes, Human, Pair 2 / genetics
Chromosomes, Human, Pair 2 / metabolism
Humans
Neoplasm Proteins / genetics
Neoplasm Proteins / metabolism*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
T-Lymphocytes / metabolism*
T-Lymphocytes / pathology
Translocation, Genetic
Zinc Finger E-box Binding Homeobox 2 / genetics
Zinc Finger E-box Binding Homeobox 2 / metabolism*

Substances

Neoplasm Proteins
ZEB2 protein, human
Zinc Finger E-box Binding Homeobox 2