Near-ubiquitous presence of a vancomycin-resistant Enterococcus faecium ST117/CT71/ van B -clone in the Rhine-Main metropolitan area of Germany

Antimicrob Resist Infect Control. 2019 Jul 29:8:128. doi: 10.1186/s13756-019-0573-8. eCollection 2019.

Abstract

Whole-genome sequencing analysis of Vancomycin-resistant Enterococcus faecium isolates from the Frankfurt metropolitan region revealed that 78/94 isolates were MLST type ST117, cgMLST complex type CT71 with a common vanB chromosomal insertion site. This indicates circulation of a single VRE clone in a catchment area of 5,000-km2 with 3 million inhabitants.

Keywords: ST117; VRE; WGS; cgMLST.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Proteins / genetics*
  • Catchment Area, Health
  • Child
  • Child, Preschool
  • Enterococcus faecium / classification*
  • Enterococcus faecium / genetics
  • Enterococcus faecium / isolation & purification*
  • Female
  • Genome, Human
  • Germany
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Phylogeny
  • Vancomycin-Resistant Enterococci / genetics
  • Vancomycin-Resistant Enterococci / isolation & purification
  • Whole Genome Sequencing / methods*
  • Young Adult

Substances

  • Bacterial Proteins
  • VanB protein, Enterococcus