Abstract
We have studied IgG F(ab')2 fractions in the plasma from a patient during spontaneous remission from lupus anticoagulant (LAC). Fractions from the remission period inhibited the LAC activity of preremission fractions, as evaluated by in vitro coagulation tests. Idiotypic/anti-idiotypic interactions were demonstrated by affinity chromatography. The same results were obtained with IgG F(ab')2 from pooled normal plasma. This enables us to treat the LAC relapse in this patient with purified recurrent anti-idiotypic determinant antibodies extracted from normal plasma.
MeSH terms
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Adult
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Antibodies, Anti-Idiotypic / analysis
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Antibodies, Anti-Idiotypic / immunology*
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Autoantibodies / immunology*
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Blood Coagulation Factors / analysis
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Blood Coagulation Factors / immunology*
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Chromatography, Affinity
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Female
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Humans
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Immunoglobulin Fab Fragments / isolation & purification
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Immunoglobulin G / isolation & purification
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Immunoglobulin Idiotypes / analysis
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Immunoglobulin Idiotypes / immunology*
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Lupus Coagulation Inhibitor
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Lupus Erythematosus, Systemic / immunology*
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Lupus Erythematosus, Systemic / therapy
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Phospholipids / immunology*
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Recurrence
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Remission, Spontaneous
Substances
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Antibodies, Anti-Idiotypic
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Autoantibodies
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Blood Coagulation Factors
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Immunoglobulin Fab Fragments
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Immunoglobulin G
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Immunoglobulin Idiotypes
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Lupus Coagulation Inhibitor
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Phospholipids