Shuttling HDL Cholesterol to the Membrane via Metastable Receptor Multimers

Elina Ikonen; Kristiina Kanerva

doi:10.1016/j.devcel.2019.07.018

Shuttling HDL Cholesterol to the Membrane via Metastable Receptor Multimers

Dev Cell. 2019 Aug 5;50(3):257-258. doi: 10.1016/j.devcel.2019.07.018.

Authors

Elina Ikonen¹, Kristiina Kanerva²

Affiliations

¹ Faculty of Medicine, Department of Anatomy and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland. Electronic address: [email protected].
² Faculty of Medicine, Department of Anatomy and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland.

PMID: 31386858
DOI: 10.1016/j.devcel.2019.07.018

Abstract

In this issue of Developmental Cell, Marques et al. (2019) provide evidence that the main receptor for high-density lipoporoteins (HDL), scavenger receptor B1 (SR-B1), forms large and dynamic homo-multimers at the plasma membrane. This helps the receptor to evade endocytosis, bind HDL, and facilitate selective lipid uptake from HDL.

Publication types

Comment

MeSH terms

Biological Transport
Cell Membrane
Cholesterol, HDL
Endocytosis*
Scavenger Receptors, Class B

Substances

Cholesterol, HDL
Scavenger Receptors, Class B