Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing

Prenat Diagn. 2019 Nov;39(12):1162-1165. doi: 10.1002/pd.5544. Epub 2019 Aug 28.

Abstract

What's already known about this topic?

  1. Incidental diagnoses of an occult maternal malignancy have been reported upon aberrant routine noninvasive prenatal testing (NIPT).

  2. The presence of tumor‐derived cell‐free DNA in the maternal circulation can skew the NIPT profile.

What does this study add?

  1. Pregnant women with a confirmed neoplastic disease should not have NIPT testing for fetal aneuploidy screening since NIPT results cannot accurately be applied to assess the fetal chromosomal constitution in this condition.

Publication types

  • Letter

MeSH terms

  • Cell-Free Nucleic Acids / analysis
  • Cell-Free Nucleic Acids / blood*
  • Chromosome Aberrations / embryology
  • Chromosome Aberrations / statistics & numerical data
  • Cohort Studies
  • DNA, Neoplasm / analysis
  • DNA, Neoplasm / blood*
  • False Negative Reactions
  • False Positive Reactions
  • Female
  • Fetus / metabolism
  • Genetic Diseases, Inborn / blood
  • Genetic Diseases, Inborn / diagnosis*
  • Genetic Diseases, Inborn / epidemiology
  • Humans
  • Noninvasive Prenatal Testing / standards*
  • Noninvasive Prenatal Testing / statistics & numerical data
  • Ploidies
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Complications, Neoplastic / blood*
  • Pregnancy Complications, Neoplastic / diagnosis
  • Pregnancy Complications, Neoplastic / epidemiology
  • Pregnancy Complications, Neoplastic / therapy*
  • Prenatal Diagnosis / methods
  • Prenatal Diagnosis / standards
  • Prenatal Diagnosis / statistics & numerical data

Substances

  • Cell-Free Nucleic Acids
  • DNA, Neoplasm