Objective: To summarize and analyze the research progress of scaffold materials used in tissue engineered meniscus.
Methods: The classification and bionics design of scaffold materials were summarized by consulting domestic and foreign literature related to the research of tissue engineered meniscus in recent years.
Results: Tissue engineered meniscus scaffolds can be roughly classified into synthetic polymers, hydrogels, extracellular matrix components, and tissue derived materials. These different materials have different characteristics, so the use of a single material has its unique disadvantages, and the use of a variety of materials composite scaffolds can learn from each other, which is a hot research area at present. In addition to material selection, material processing methods are also the focus of research. At the same time, according to the morphological structure and mechanical characteristics of the meniscus, the bionic design of tissue engineered meniscus scaffolds has great potential.
Conclusion: At present, there are many kinds of scaffold materials for tissue engineered meniscus. However, there is no material that can completely simulate the natural meniscus, and further research of scaffold materials is still needed.
目的: 总结组织工程半月板支架材料的研究进展。.
方法: 查阅近年来国内外组织工程半月板研究相关文献,对支架材料分类和仿生设计进行总结。.
结果: 目前组织工程半月板支架材料可大致分为人工合成聚合物、水凝胶、细胞外基质组分和组织衍生材料 4 类。上述材料具有不同特性,使用单一材料制备的支架具有一定缺陷,因此采用多种材料制备复合支架,以期发挥各种材料优势,是目前研究热点。除了材料选择外,材料加工方式也是研究重点。综合材料选择与加工方式,根据半月板形态结构与力学特点进行仿生设计的组织工程半月板支架具有较大潜力。.
结论: 目前组织工程半月板支架材料选择较多,但尚无一种材料能完全模拟天然半月板,有待进一步研究。.
Keywords: Tissue engineered meniscus; bionic design; scaffold material.