A treatment approach for couples with disrupted sperm DNA integrity and recurrent ART failure

J Assist Reprod Genet. 2019 Oct;36(10):2057-2066. doi: 10.1007/s10815-019-01543-5. Epub 2019 Aug 16.

Abstract

Objective: To test a novel method to select spermatozoa with high chromatin integrity.

Design: Specimens with high sperm chromatin fragmentation (SCF) were selected by density gradient selection (DGS) and microfluidic sperm sorting (MSS).

Setting: Academic medical center.

Patient(s): Ejaculates from consenting men were processed by DGS/MSS. Couples underwent ICSI cycles with spermatozoa processed by DGS/MSS. Clinical outcomes were evaluated after embryo transfer.

Intervention(s): SCF was measured by TUNEL. ICSI with spermatozoa selected by DGS and MSS was performed.

Main outcome measure(s): Fertilization, embryo implantation, and pregnancy outcomes were compared between DGS and MSS.

Result(s): A total of 23 men had an average SCF of 20.7 ± 10%. After DGS and MSS, the SCF was 12.5 ± 5% and 1.8 ± 1%, respectively. In couples who underwent ICSI, the average SCF was 28.8 ± 9%, which fell to 21.0 ± 9% after DGS and 1.3 ± 0.7% after MSS. Four couples underwent 11 ICSI cycles with DGS and achieved one (25%) pregnancy that resulted in pregnancy loss. In four subsequent ICSI cycles with MSS, an ongoing clinical pregnancy rate of 50% was achieved. Five additional couples underwent 12 cycles of ICSI with DGS. After preimplantation genetic testing for aneuploidy, 30.3% of the embryos were euploid. One pregnancy was achieved, resulting in pregnancy loss. With MSS, 31.5% of the embryos were euploid and 4 couples obtained a pregnancy. Finally, sixteen couples underwent 20 ICSI cycles solely with MSS at our center. Of these couples, 8 had failed 13 ICSI cycles with DGS elsewhere. These couples achieved an overall implantation of 34.5% (10/29) and a pregnancy rate of 58.8% (10/17).

Conclusion(s): Microfluidic selection yielded spermatozoa with optimal genomic integrity and improved chances of obtaining a euploid conceptus.

Keywords: Assisted reproductive technologies; Density gradient selection; ICSI; Microfluidic chamber; Sperm chromatin fragmentation.

MeSH terms

  • Abortion, Spontaneous / epidemiology*
  • Abortion, Spontaneous / pathology
  • Adult
  • Chromatin / genetics
  • Chromatin / ultrastructure*
  • DNA / genetics
  • DNA / ultrastructure*
  • DNA Fragmentation
  • Embryo Implantation / genetics
  • Embryo Transfer / methods
  • Family Characteristics
  • Female
  • Fertilization in Vitro
  • Humans
  • Infertility, Male / genetics*
  • Male
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Rate
  • Reproductive Techniques, Assisted / adverse effects
  • Spermatozoa / pathology
  • Spermatozoa / ultrastructure*

Substances

  • Chromatin
  • DNA