Short Communication: Extremely Severe CD4 Lymphopenia During HIV-1 Primary Infection

AIDS Res Hum Retroviruses. 2019 Oct;35(10):930-933. doi: 10.1089/AID.2019.0065. Epub 2019 Sep 12.

Abstract

We report the case of a patient with a very profound CD4 T cell lymphopenia <20 cells/mm3 in the context of a primary HIV-1 infection, associated with both delayed HIV-specific antibody and CD8 T cell responses. A long-term immune reconstitution was observed after immediate initiation of antiretroviral therapy.

Keywords: CD4; HIV; T cell; antibody; immunosuppression; primary HIV infection.

Publication types

  • Case Reports

MeSH terms

  • Blotting, Western
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes*
  • CD8-Positive T-Lymphocytes
  • Candidiasis, Oral / etiology
  • Candidiasis, Oral / immunology
  • Enzyme-Linked Immunosorbent Assay
  • False Negative Reactions
  • Female
  • France
  • Genotype
  • HIV Core Protein p24 / blood
  • HIV Infections / blood
  • HIV Infections / immunology*
  • HIV Seronegativity / immunology*
  • HIV Seropositivity
  • HIV-1* / genetics
  • HIV-1* / isolation & purification
  • Humans
  • Lymphopenia / blood
  • Lymphopenia / etiology*
  • Lymphopenia / immunology
  • Middle Aged
  • Nigeria / ethnology
  • Protein Precursors / blood
  • Viremia / blood
  • Viremia / immunology*

Substances

  • HIV Core Protein p24
  • Protein Precursors
  • p55 gag precursor protein, Human immunodeficiency virus 1