Safety Report of TAS-102 in a Patient With Reduced DPD Activity

Clin Colorectal Cancer. 2019 Dec;18(4):310-312. doi: 10.1016/j.clcc.2019.07.008. Epub 2019 Jul 29.
No abstract available

Keywords: DPD-deficiency; DPYD gene; Lonsurf; Trifluridine/tipiriracil; mCRC.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Dihydropyrimidine Dehydrogenase Deficiency / drug therapy*
  • Dihydropyrimidine Dehydrogenase Deficiency / pathology
  • Dihydrouracil Dehydrogenase (NADP) / metabolism*
  • Drug Combinations
  • Drug Resistance, Neoplasm / drug effects*
  • Female
  • Humans
  • Patient Safety
  • Prognosis
  • Pyrrolidines / therapeutic use*
  • Rectal Neoplasms / drug therapy*
  • Rectal Neoplasms / enzymology
  • Rectal Neoplasms / pathology
  • Thymine
  • Trifluridine / therapeutic use*
  • Uracil / analogs & derivatives*
  • Uracil / therapeutic use

Substances

  • Antineoplastic Agents
  • Drug Combinations
  • Pyrrolidines
  • trifluridine tipiracil drug combination
  • Uracil
  • Dihydrouracil Dehydrogenase (NADP)
  • Thymine
  • Trifluridine