Single fraction urethra-sparing prostate cancer SBRT: Phase I results of the ONE SHOT trial

Thomas Zilli; Ciro Franzese; Marta Bottero; Niccolò Giaj-Levra; Robert Förster; Daniel Zwahlen; Nikolaos Koutsouvelis; Aurelie Bertaut; Julie Blanc; Giuseppe Roberto D'agostino; Filippo Alongi; Matthias Guckenberger; Marta Scorsetti; Raymond Miralbell

doi:10.1016/j.radonc.2019.07.018

Single fraction urethra-sparing prostate cancer SBRT: Phase I results of the ONE SHOT trial

Radiother Oncol. 2019 Oct:139:83-86. doi: 10.1016/j.radonc.2019.07.018. Epub 2019 Aug 17.

Affiliations

¹ Radiation Oncology, Geneva University Hospital, Switzerland; Faculty of Medicine, Geneva University, Switzerland. Electronic address: [email protected].
² Radiation Oncology, Humanitas Research Hospital and Cancer Center, Milan, Italy.
³ Radiation Oncology, Geneva University Hospital, Switzerland.
⁴ Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don-Calabria, Negrar, Italy.
⁵ Radiation Oncology, University Hospital Zürich, Switzerland.
⁶ Radiation Oncology, Kantonsspital Graubünden, Chur, Switzerland.
⁷ Methodology and Biostatistics Unit, Centre Georges François Leclerc, Dijon, France.
⁸ Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don-Calabria, Negrar, Italy; University of Brescia, Faculty of Medicine, Brescia, Italy.
⁹ Radiation Oncology, Humanitas University, Milan, Italy; Radiation Oncology, Humanitas Research Hospital and Cancer Center, Milan, Italy.
¹⁰ Radiation Oncology, Geneva University Hospital, Switzerland; Faculty of Medicine, Geneva University, Switzerland.

PMID: 31431369
DOI: 10.1016/j.radonc.2019.07.018

Abstract

The ONE SHOT trial is the first phase I/II prospective, multicenter, single-arm study assessing the efficacy and safety of a single-dose SBRT for men with localized prostate cancer. Aim of this paper is to present the phase I results of a 19 Gy single fraction urethra-sparing SBRT with real-time electromagnetic tracking.

Keywords: Monotherapy; Phase I/II trial; Prostate cancer; SBRT; Toxicity.

Publication types

Clinical Trial, Phase I
Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Humans
Male
Prospective Studies
Prostatic Neoplasms / radiotherapy*
Radiosurgery / methods*
Radiotherapy, Image-Guided / methods*
Urethra / radiation effects*