Sweet Memories of 8 Empowered by Butyrate

Liangliang Ji; Xiaoyu Hu

doi:10.1016/j.immuni.2019.07.005

Sweet Memories of 8 Empowered by Butyrate

Immunity. 2019 Aug 20;51(2):201-203. doi: 10.1016/j.immuni.2019.07.005.

Authors

Liangliang Ji¹, Xiaoyu Hu²

Affiliations

¹ Institute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing 100084, China.
² Institute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing 100084, China. Electronic address: [email protected].

PMID: 31433964
DOI: 10.1016/j.immuni.2019.07.005

Abstract

Formation of memory T cells is coupled with changes of metabolic status, yet how environmental metabolites affect the transition remains largely unknown. In this issue of Immunity, Bachem et al. (2019) report that microbiota-derived butyrate enhances the memory potential of CD8⁺ T cells via rewiring cellular metabolism.

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MeSH terms

Butyrates*
CD8-Positive T-Lymphocytes
Microbiota*

Substances

Butyrates