Abstract
Different from traditional "always on" photothermal therapy (PTT) agents, tumor microenvironment responsive agents showed more tumor specificity and lower photo-toxicity to normal tissues. Herein, a photo-stable and reversible pH responsive phenazine dye (PIOH) was synthesized and assembled with liposomes forming nanoparticles (PIOH-NPs), which exhibited a strong NIR absorption in a weak acid environment and were successfully utilized for photoacoustic (PA) imaging-guided photothermal therapy in mice.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Agents / toxicity
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Cholesterol / chemistry
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Female
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / therapeutic use*
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Fluorescent Dyes / toxicity
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Hydrogen-Ion Concentration
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Hyperthermia, Induced / methods
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Lecithins / chemistry
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Liposomes / chemistry
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Mice, Inbred BALB C
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Nanoparticles / chemistry
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Particle Size
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Phenazines / chemical synthesis
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Phenazines / chemistry
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Phenazines / therapeutic use*
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Phenazines / toxicity
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Photoacoustic Techniques / methods
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Phototherapy / methods
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Tumor Microenvironment / physiology
Substances
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Antineoplastic Agents
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Fluorescent Dyes
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Lecithins
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Liposomes
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Phenazines
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Cholesterol