Microenvironment meets lineage complexity in junctional tumorigenesis

Wa Xian; Frank McKeon

doi:10.1038/s41467-019-11651-6

Microenvironment meets lineage complexity in junctional tumorigenesis

Nat Commun. 2019 Aug 23;10(1):3829. doi: 10.1038/s41467-019-11651-6.

Authors

Wa Xian^{1

2}, Frank McKeon³

Affiliations

¹ Institute of Molecular Medicine, McGovern Medical School of The University of Texas Health Science Center, Houston, TX, 77030, USA.
² Department of Biochemistry and Molecular Biology, University of Texas McGovern Medical School, Houston, TX, 77030, USA.
³ Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA. [email protected].

Abstract

Using a sensitizing genetic model, Moon and colleagues provide compelling data for a determinant role of microenvironment in tumorigenesis, and lend support to the notion that such influences can be pharmacologically dampened to reduce the onset of cancers.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Carcinogenesis
Cell Transformation, Neoplastic
Cyclooxygenase 2
Gastric Acid*
Humans
Keratin-5
Neoplasms*
Tumor Microenvironment

Substances

KRT5 protein, human
Keratin-5
Cyclooxygenase 2

Abstract

Publication types

MeSH terms

Substances

Grants and funding