The utility of adrenal and ovarian venous sampling in a progesterone-producing adrenal tumor and review of the literature

Endocrine. 2019 Nov;66(2):319-325. doi: 10.1007/s12020-019-02007-7. Epub 2019 Aug 27.

Abstract

Purpose: A clinical case presenting secondary amenorrhea accompanied by an adrenal adenoma and hyperprogesteronemia is described in this study.

Methods: Selective catheterization and sampling of adrenal and ovarian veins were performed.

Results: The source of hyperprogesteronemia was located in the right adrenal gland. A progesterone-producing tumor in the right adrenal gland was diagnosed and removed. Twenty-six days after tumor resection, menstruation occurred.

Conclusions: Progesterone-producing tumors should be considered with the presence of an adrenal mass and hyperprogesteronemia. Combined adrenal and ovarian venous sampling may help to identify the source of progesterone secretion.

Keywords: Amenorrhea; Combined adrenal and ovarian venous sampling; Progesterone-producing tumor.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenal Cortex Neoplasms / complications*
  • Adrenal Cortex Neoplasms / metabolism*
  • Adrenal Cortex Neoplasms / pathology
  • Adrenal Cortex Neoplasms / surgery
  • Adrenal Glands / blood supply*
  • Adrenal Glands / pathology
  • Adrenal Glands / surgery
  • Adrenocortical Adenoma / complications*
  • Adrenocortical Adenoma / metabolism
  • Adrenocortical Adenoma / pathology
  • Adrenocortical Adenoma / surgery
  • Adult
  • Amenorrhea / etiology*
  • Amenorrhea / metabolism
  • Amenorrhea / pathology
  • Amenorrhea / surgery
  • Blood Specimen Collection / methods*
  • Female
  • Humans
  • Ovary / blood supply*
  • Progesterone / blood*
  • Treatment Outcome

Substances

  • Progesterone