Establishment of an efficient reverse genetic system of Mumps virus S79 from cloned DNA

World J Pediatr. 2019 Oct;15(5):499-505. doi: 10.1007/s12519-019-00286-8. Epub 2019 Aug 28.

Abstract

Background: Mumps is a common type of respiratory infectious disease caused by mumps virus (MuV), and can be effectively prevented by vaccination. In this study, a reverse genetic system of MuV that can facilitate the rational design of safer, more efficient mumps vaccine candidates is established.

Methods: MuV-S79 cDNA clone was assembled into a full-length plasmid by means of the GeneArt™ High-Order Genetic Assembly System, and was rescued via reverse genetic technology. RT-PCR, sequencing, and immunofluorescence assays were used for rMuV-S79 authentication. Viral replication kinetics and in vivo experimental models were used to evaluate the replication, safety, and immunogenicity of rMuV-S79.

Results: A full-length cDNA clone of MuV-S79 in the assembly process was generated by a novel plasmid assemble strategy, and a robust reverse genetic system of MuV-S79 was successfully established. The established rMuV-S79 strain could reach a high virus titer in vitro. The average viral titer of rMuV-S79 in the lung tissues was 2.68 ± 0.14 log10PFU/g lung tissue, and rMuV-S79 group did not induce inflammation in the lung tissues in cotton rats. Neutralizing antibody titers induced by rMuV-S79 were high, long-lasting and could provide complete protection against MuV wild strain challenge.

Conclusion: We have established a robust reverse genetic system of MuV-S79 which can facilitate the optimization of mumps vaccines. rMuV-S79 rescued could reach a high virus titer and the safety was proven in vivo. It could also provide complete protection against MuV wild strain challenge.

Keywords: Immunogenicity; Mumps virus; Plasmid; Reverse genetics; Safety.

MeSH terms

  • Animals
  • Cloning, Molecular
  • DNA, Viral / genetics
  • Genome, Viral
  • Humans
  • Mumps / genetics*
  • Mumps / prevention & control*
  • Mumps Vaccine / genetics*
  • Mumps virus / genetics*
  • Rats
  • Reverse Genetics*

Substances

  • DNA, Viral
  • Mumps Vaccine

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