Human Neutrophil Elastase Induces MUC5AC Overexpression in Chronic Rhinosinusitis Through miR-146a

Am J Rhinol Allergy. 2020 Jan;34(1):59-69. doi: 10.1177/1945892419871798. Epub 2019 Aug 29.

Authors

Danqing Yan¹, Yu Ye¹, Jian Zhang¹, Junmei Zhao¹, Jieqing Yu¹, Qing Luo¹

Affiliation

¹ Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, P.R. China.

PMID: 31466461
DOI: 10.1177/1945892419871798

No abstract available

Keywords: MUC5AC; chronic rhinosinusitis; epidermal growth factor receptor; human neutrophil elastase; microRNA-146a.

MeSH terms

Adolescent
Adult
Aged
Blotting, Western
Cells, Cultured
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Epithelial Cells / metabolism
Epithelial Cells / pathology
Female
Gene Expression Regulation*
Humans
Leukocyte Elastase / genetics*
Leukocyte Elastase / metabolism
Male
MicroRNAs / genetics*
MicroRNAs / metabolism
Middle Aged
Mucin 5AC / biosynthesis
Mucin 5AC / genetics*
Nasal Mucosa / metabolism
Nasal Mucosa / pathology
RNA / genetics*
Rhinitis / genetics*
Rhinitis / metabolism
Rhinitis / pathology
Sinusitis / genetics*
Sinusitis / metabolism
Sinusitis / pathology
Young Adult

Substances

MIRN146 microRNA, human
MUC5AC protein, human
MicroRNAs
Mucin 5AC
RNA
ELANE protein, human
Leukocyte Elastase