TwinBLAST: When Two Is Better than One

Julie C Dunning Hotopp; James Matsumura; Robin E Bromley; David R Riley; Sonia Agrawal; Ben Sparklin; John Mattick; Jonathan Crabtree; Anup Mahurkar

doi:10.1128/MRA.00842-19

TwinBLAST: When Two Is Better than One

Microbiol Resour Announc. 2019 Aug 29;8(35):e00842-19. doi: 10.1128/MRA.00842-19.

Authors

Julie C Dunning Hotopp^{1

2

3}, James Matsumura⁴, Robin E Bromley⁴, David R Riley⁴, Sonia Agrawal⁴, Ben Sparklin⁴, John Mattick⁴, Jonathan Crabtree⁴, Anup Mahurkar⁴

Affiliations

¹ Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA [email protected].
² Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
³ Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
⁴ Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Abstract

Analysis of sequence read pairs can be essential for characterizing structural variation, including junction-spanning pairs of reads (JSPRs) suggesting recent lateral/horizontal gene transfer. TwinBLAST can be used to facilitate this analysis of JSPRs by enabling the visualization and curation of two BLAST reports side by side in a single interface.

Grants and funding

R01 CA206188/CA/NCI NIH HHS/United States