Innate lymphoid cells and cancer at border surfaces with the environment

Irene Mattiola; Andreas Diefenbach

doi:10.1016/j.smim.2019.06.001

Innate lymphoid cells and cancer at border surfaces with the environment

Semin Immunol. 2019 Feb:41:101278. doi: 10.1016/j.smim.2019.06.001. Epub 2019 Aug 28.

Authors

Irene Mattiola¹, Andreas Diefenbach²

Affiliations

¹ Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany; Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, 10117 Berlin, Germany; Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Charitéplatz 1, 10117 Berlin, Germany.
² Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany; Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, 10117 Berlin, Germany; Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: [email protected].

PMID: 31473072
DOI: 10.1016/j.smim.2019.06.001

Abstract

Innate lymphoid cells (ILC) are a recently identified group of innate lymphocytes. ILC are subdivided into cytotoxic ILC (i.e., conventional natural killer (NK) cells) and helper ILC. Helper ILC are tissue-resident cells that have been involved in various physiological and pathological processes of organs and tissues. While their roles during inflammation are well studied, their contribution to tumor immunity is not well known. Here, we will provide an overview of the various helper ILC subsets, their development and function and discuss their potential roles during tumorigenesis and for anti-tumor immunity at border surface with the environment.

Keywords: Barrier tissues; Cancer; ILC.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Transformation, Neoplastic / immunology
Cell Transformation, Neoplastic / metabolism
Disease Susceptibility
Humans
Immunity, Innate*
Lymphocytes / immunology*
Lymphocytes / metabolism*
Lymphocytes / pathology
Lymphocytes, Tumor-Infiltrating / immunology
Lymphocytes, Tumor-Infiltrating / metabolism
Lymphocytes, Tumor-Infiltrating / pathology
Mice
Neoplasm Grading
Neoplasms / etiology*
Neoplasms / metabolism*
Neoplasms / pathology
Tumor Microenvironment / immunology*