Association of single nucleotide polymorphisms in TNFA and CCR5 genes with Japanese Encephalitis: A study from an endemic region of North India

J Neuroimmunol. 2019 Nov 15:336:577043. doi: 10.1016/j.jneuroim.2019.577043. Epub 2019 Aug 26.

Abstract

TNFA, IL1B, HMGB1, IL10, CXCL8, CCL2 and CCR5 gene polymorphisms were investigated in 183 Japanese Encephalitis (JE) cases and 361 healthy controls from North India. Higher frequency of TNFA rs1800629 G/A, CCR5 rs1799987 genotypes with A allele and lower frequency of combination lacking TNFA rs1800629 A, CCR5 rs333 Δ32, andCCR5 rs1799987 A alleles and CCL2 rs1024611 G/G genotype was observed in JE cases. TNFA rs1800629 A and CCR5 rs1799987 A alleles were associated with susceptibility while combination lacking TNFA rs1800629 A, CCR5 rs333 Δ32, and rs1799987 A alleles and CCL2 rs1024611 G/G genotype was associated with protection to JE.

Keywords: Acute encephalitis syndrome; Chemokine; Chemokine receptor; Cytokine; Japanese Encephalitis; Single nucleotide polymorphisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Encephalitis, Japanese / blood
  • Encephalitis, Japanese / epidemiology*
  • Encephalitis, Japanese / genetics*
  • Endemic Diseases*
  • Female
  • Humans
  • India
  • Male
  • Polymorphism, Single Nucleotide / genetics*
  • Receptors, CCR5 / blood
  • Receptors, CCR5 / genetics*
  • Tumor Necrosis Factor-alpha / blood
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • CCR5 protein, human
  • Receptors, CCR5
  • Tumor Necrosis Factor-alpha