Luminescent Porous Silicon Nanoparticles for Continuous Wave and Time-Gated Photoluminescence Imaging

Tushar Kumeria; Zhi Qu; Amirali Popat; Tariq Altalhi; Abel Santos

doi:10.1007/978-1-4939-9769-5_13

Luminescent Porous Silicon Nanoparticles for Continuous Wave and Time-Gated Photoluminescence Imaging

Methods Mol Biol. 2019:2054:185-198. doi: 10.1007/978-1-4939-9769-5_13.

Authors

Tushar Kumeria^{1

2}, Zhi Qu^{3

4}, Amirali Popat^{3

4}, Tariq Altalhi⁵, Abel Santos^{6

7

8}

Affiliations

¹ School of Pharmacy, Pharmacy Australia Center of Excellence, The University of Queensland, Woolloongabba, QLD, Australia. [email protected].
² Mater Research Institute, Translational Research Institute, The University of Queensland, Woolloongabba, QLD, Australia. [email protected].
³ School of Pharmacy, Pharmacy Australia Center of Excellence, The University of Queensland, Woolloongabba, QLD, Australia.
⁴ Mater Research Institute, Translational Research Institute, The University of Queensland, Woolloongabba, QLD, Australia.
⁵ Department of Chemistry, Faculty of Science, Taif University, Taif, Saudi Arabia.
⁶ School of Chemical Engineering and Advanced Materials, The University of Adelaide, Adelaide, SA, Australia.
⁷ Institute for Photonics and Advanced Sensing (IPAS), The University of Adelaide, Adelaide, SA, Australia.
⁸ ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), The University of Adelaide, Adelaide, SA, Australia.

PMID: 31482457
DOI: 10.1007/978-1-4939-9769-5_13

Abstract

Luminescent porous silicon nanoparticles (LpSiNPs) display red-orange photoluminescence (PL) that provides large penetration depth for precise deep-tissue imaging and diagnostics. Herein, we describe in detail the fabrication process of porous silicon nanoparticles (pSiNPs), activation of photoluminescence, quantum yield measurement, and PL imaging. LpSiNPs perform as imaging probe for both the continuous wave and time-gated PL imaging.

Keywords: Photoluminescence; Porous silicon nanoparticles; Quantum dots; Quantum yield; Time-gated imaging.

MeSH terms

Animals
Fluorescent Dyes / chemistry
Intravital Microscopy / methods
Luminescence*
Mice
Molecular Imaging / methods
Molecular Probes / chemistry*
Nanoparticles / chemistry*
Porosity
Silicon / chemistry*

Substances

Fluorescent Dyes
Molecular Probes
Silicon