Successful re-transplantation in patient with recurrent parvovirus B19 pure red cell aplasia

Neeraj Inamdar; Ritambhra Nada; Ranjana Minz; Deepesh Benjamin Kenwar; Sarabpreet Singh; Ashish Sharma; Vivek Kumar; Manish Rathi; Harbir S Kohli; Raja Ramachandran

doi:10.1111/tid.13164

Successful re-transplantation in patient with recurrent parvovirus B19 pure red cell aplasia

Transpl Infect Dis. 2019 Dec;21(6):e13164. doi: 10.1111/tid.13164. Epub 2019 Sep 21.

Authors

Affiliations

¹ Department of Nephrology, Post graduate Institute of Medical Education and Research, Chandigarh, India.
² Department of Histopathology, Post graduate Institute of Medical Education and Research, Chandigarh, India.
³ Department of Immunopathology, Post graduate Institute of Medical Education and Research, Chandigarh, India.
⁴ Department of Transplant Surgery, Post graduate Institute of Medical Education and Research, Chandigarh, India.

PMID: 31483919
DOI: 10.1111/tid.13164

Abstract

Impaired cell-mediated, as well as antibody-mediated immunity predisposes a renal transplant recipient to a wide variety of atypical infection. With an increasing number of re-transplant, the balance between immunosuppression and the risk of recurrent disease poses a clinical and therapeutic challenge. Here, we report a successful re-transplantation in a case of parvovirus B19 infection leading to anaemia and collapsing glomerulopathy in the allograft managed with intravenous immunoglobulin (IVIG) and reduction of immunosuppression. This case emphasizes re-consideration to renal transplant after clearance of the virus in a previous renal allograft lost to PVB19 infection.

Keywords: collapsing glomerulopathy; parvovirus B19; pure red cell aplasia; re-transplantation.

Publication types

Case Reports

MeSH terms

Allografts / immunology
Allografts / virology
Erythema Infectiosum / complications
Erythema Infectiosum / drug therapy*
Erythema Infectiosum / immunology
Erythema Infectiosum / virology
Glomerulonephritis / immunology
Glomerulonephritis / surgery
Graft Rejection / immunology
Graft Rejection / therapy*
Graft Rejection / virology
Humans
Immunocompromised Host
Immunoglobulins, Intravenous / therapeutic use*
Immunosuppressive Agents / adverse effects
Kidney / immunology
Kidney / virology
Kidney Transplantation / adverse effects*
Living Donors
Male
Parvovirus B19, Human / immunology
Parvovirus B19, Human / isolation & purification*
Recurrence
Red-Cell Aplasia, Pure / drug therapy
Red-Cell Aplasia, Pure / etiology*
Reoperation
Transplantation, Haploidentical / adverse effects
Treatment Outcome
Young Adult

Substances

Immunoglobulins, Intravenous
Immunosuppressive Agents