Replacement of an Implantable Cardioverter-Defibrillator (ICD) with a New Standard Subcutaneous ICD System in a Patient with Jervell and Lange-Nielsen Syndrome

Int Heart J. 2019 Sep 27;60(5):1206-1210. doi: 10.1536/ihj.19-076. Epub 2019 Sep 4.

Abstract

A 7-year-old female suffering from syncope attacks and deafness was genetically diagnosed with Jervell and Lange-Nielsen syndrome (JLNS). A transvenous-designed shock lead and implantable cardioverter-defibrillator (ICD) were atypically implanted subcutaneously, because the patient's body was small. Six years after implantation, we confirmed the patient's eligibility for a subcutaneous ICD (S-ICD) based on electrocardiogram screening. The implanted ICD system was replaced with a new standard S-ICD system. Implantation of the S-ICD may be considered a reliable and safe option in young patients with JLNS, even if their electrocardiograms show remarkable prolongation of the QT interval and T-wave alternans.

Keywords: KCNQ1; Long QT syndrome.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Defibrillators, Implantable / adverse effects*
  • Device Removal / methods
  • Electrocardiography / methods*
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Jervell-Lange Nielsen Syndrome / complications
  • Jervell-Lange Nielsen Syndrome / diagnosis*
  • Jervell-Lange Nielsen Syndrome / therapy*
  • KCNQ1 Potassium Channel / genetics*
  • Pedigree
  • Retreatment
  • Syncope / diagnosis
  • Syncope / etiology
  • Syncope / therapy
  • Time Factors
  • Treatment Outcome

Substances

  • KCNQ1 Potassium Channel