RUNX transcription factors: orchestrators of development

Development. 2019 Sep 5;146(17):dev148296. doi: 10.1242/dev.148296.

Abstract

RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.

Keywords: Bone; Development; Embryonic; Hematopoiesis; RUNX; T cell.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Core Binding Factor alpha Subunits / genetics*
  • Core Binding Factor alpha Subunits / metabolism*
  • Gene Expression Regulation, Developmental
  • Genetic Loci
  • Hematopoiesis / physiology
  • Homeostasis / physiology
  • Humans
  • Mammals / embryology*
  • Mammals / metabolism*
  • Mice
  • Neoplasms / metabolism

Substances

  • Core Binding Factor alpha Subunits