Changing the Rules of the Game: How Winners Become Losers during Oncogenic Cell Selection

Cristina Villa Del Campo; Miguel Torres

doi:10.1016/j.stem.2019.08.006

Changing the Rules of the Game: How Winners Become Losers during Oncogenic Cell Selection

Cell Stem Cell. 2019 Sep 5;25(3):299-300. doi: 10.1016/j.stem.2019.08.006.

Authors

Cristina Villa Del Campo¹, Miguel Torres²

Affiliations

¹ Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain.
² Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain. Electronic address: [email protected].

PMID: 31491391
DOI: 10.1016/j.stem.2019.08.006

Abstract

As we age, our tissues become a mosaic of random mutations, many of which are oncogenic and promote the expansion of their carrier cells. In this issue of Cell Stem Cell, Fernandez-Antoran et al. (2019) show how commonly used medical procedures modify cell selection dynamics to either expand or eliminate cells carrying oncogenic p53 mutations.

Publication types

Comment

MeSH terms

Esophagus
Mutation
Oncogenes*
Oxidation-Reduction
Tumor Suppressor Protein p53*

Substances

Tumor Suppressor Protein p53