Electrochemical sensing of anti-inflammatory agent in paramedical sample based on FeMoSe2 modified SPCE: Comparison of various preparation methods and morphological effects

Sukanya Ramaraj; Mani Sakthivel; Shen-Ming Chen; Mohamed S Elshikh; Tse-Wei Chen; Ming-Chin Yu; Kuo-Chuan Ho

doi:10.1016/j.aca.2019.07.019

Electrochemical sensing of anti-inflammatory agent in paramedical sample based on FeMoSe₂ modified SPCE: Comparison of various preparation methods and morphological effects

Anal Chim Acta. 2019 Nov 20:1083:88-100. doi: 10.1016/j.aca.2019.07.019. Epub 2019 Jul 10.

Authors

Sukanya Ramaraj¹, Mani Sakthivel², Shen-Ming Chen³, Mohamed S Elshikh⁴, Tse-Wei Chen⁵, Ming-Chin Yu⁶, Kuo-Chuan Ho⁷

Affiliations

¹ Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 10608, Taiwan.
² Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan; Advanced Research Center for Green Materials Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.
³ Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 10608, Taiwan. Electronic address: [email protected].
⁴ Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
⁵ Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 10608, Taiwan; Research and Development Center for Smart Textile Technology, National Taipei University of Technology, Taipei, 106, Taiwan, ROC.
⁶ Department of Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan, ROC. Electronic address: [email protected].
⁷ Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan; Advanced Research Center for Green Materials Science and Technology, National Taiwan University, Taipei, 10617, Taiwan. Electronic address: [email protected].

PMID: 31493811
DOI: 10.1016/j.aca.2019.07.019

Abstract

We demonstrate the different types of synthesis processes (hydrothermal, microwave and simple chemical synthesis) to prepare the Fe doped molybdenum diselenides (H-FeMoSe₂, M-FeMoSe₂, and C-FeMoSe₂) and investigate their relevant electrocatalytic activities. The Fe doped MoSe₂ exhibited an enhanced charge transfer conductivity and electrocatalytic activity. Especially, the H-FeMoSe₂ with vertically aligned structures facilitate the abundant exposed active edge sites. Thus, H-FeMoSe₂ modified screen-printed carbon electrode (H-FeMoSe₂/SPCE) exhibited the lower R_ct and better active surface area than that of M-FeMoSe₂/SPCE and C-FeMoSe₂/SPCE. As well as, the electrochemical sensing of mesalamine (MES) at H-FeMoSe₂/SPCE is comparatively 0.46 and 1.28 fold higher than that obtained at M-FeMoSe₂/SPCE and C-FeMoSe₂/SPCE respectively. Thus, H-FeMoSe₂/SPCE was concluded as an excellent electrocatalyst for sensing of MES and performed DPV technique. As the results, very low detection limit (0.8 nM) of MES was achieved at H-FeMoSe₂/SPCE. Hence, the selected H-FeMoSe₂/SPCE was successfully subjected to the real-time detection of MES by using a paramedical tablet and reported the excellent recovery range.

Keywords: Doping process; Electrochemical sensor; Hydrothermal technique; Iron; Mesalamine; Microwave assisted synthesis; Molybdenum diselenide; Simple chemical synthesis.

Publication types

Comparative Study

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / analysis*
Carbon / chemistry
Catalysis
Electrochemical Techniques / instrumentation
Electrochemical Techniques / methods
Electrodes
Iron / chemistry*
Limit of Detection
Mesalamine / analysis*
Molybdenum / chemistry*
Reproducibility of Results
Selenium Compounds / chemical synthesis
Selenium Compounds / chemistry*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Selenium Compounds
Mesalamine
Carbon
Molybdenum
Iron