Microglia in Memory Decline from Zika Virus and West Nile Virus Infection

Jennifer Tisoncik-Go; Michael Gale Jr

doi:10.1016/j.tins.2019.08.009

Microglia in Memory Decline from Zika Virus and West Nile Virus Infection

Trends Neurosci. 2019 Nov;42(11):757-759. doi: 10.1016/j.tins.2019.08.009. Epub 2019 Sep 5.

Authors

Jennifer Tisoncik-Go¹, Michael Gale Jr²

Affiliations

¹ Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA; Washington National Primate Research Center, Seattle, WA, USA.
² Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA; Washington National Primate Research Center, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA. Electronic address: [email protected].

Abstract

Neurotropic viral infection can result in complications underscored by persistent T cell presence in the brain linked with cognitive decline. A recent study by Garber et al. showed that sustained T cell production of interferon (IFN)-γ mediating microglia activation triggers cognitive decline during recovery from Zika virus (ZIKV) or West Nile virus (WNV) infection.

Keywords: flavivirus; memory; microglia.

Publication types

Comment

MeSH terms

Cognitive Dysfunction*
Flavivirus*
Humans
Memory Disorders
Microglia
T-Lymphocytes
West Nile Fever*
West Nile virus*
Zika Virus Infection*
Zika Virus*

Abstract

Publication types

MeSH terms

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