Abstract
Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared phototoxicity when excited at 760 and 810 nm. The PHT-PMO were then aminated to promote electrostatic complexation with siRNA. Transfection experiments were performed upon NIR irradiation and photochemical internalization was very efficient, leading to 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.
MeSH terms
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Cell Survival
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Cetrimonium / chemistry
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Humans
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Indoles / chemistry*
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Infrared Rays
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Isoindoles
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Luciferases / genetics
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MCF-7 Cells
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Nanoparticles / chemistry*
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Organometallic Compounds / chemistry*
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Photochemical Processes
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Photochemotherapy / methods*
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Porosity
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RNA, Small Interfering / chemistry*
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RNA, Small Interfering / metabolism
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Silanes / chemistry*
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Static Electricity
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Surface Properties
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Zinc Compounds
Substances
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Indoles
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Isoindoles
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Organometallic Compounds
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RNA, Small Interfering
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Silanes
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Zinc Compounds
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Zn(II)-phthalocyanine
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vinyltriethoxysilane
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Luciferases
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octyltriethoxysilane
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Cetrimonium