Normal gait, albumin and d-dimer levels identify low risk emergency department patients: a prospective observational cohort study with 365-day 100% follow-up

QJM. 2020 Feb 1;113(2):86-92. doi: 10.1093/qjmed/hcz226.

Abstract

Background: If survival could be reliably predicted many patients could be safely managed outside of hospital in an ambulatory care setting.

Aim: Comparison of common laboratory findings, co-morbidities, mobility and vital signs as predictors of mortality of acutely ill emergency department (ED) attendees.

Design: Prospective observational study.

Methods: Secondary analysis of 1334 consenting acutely ill patients attending a Danish ED.

Results: 67 (5%) out of 1334 patients died within 100 days. After logistic regression seven predictors of 100 days mortality remained significant: an albumin level ≤34 gm/l, D-dimer level >0.51 mg/l, an Asadollahi score (based on admission laboratory data and age) ≥12, a platelet count <159 X 1000/ml, impaired mobility on presentation, a respiratory rate ≥30 bpm and a Charlson co-morbidity index ≥3. Only 5 of the 442 without any of these variables died within 365 days. Only one of the 517 patients with a stable independent gait and normal d-dimer and albumin levels died within 100 days, none died within 30 days of assessment and 12 died within 365 days. Of the remaining 817 patients 66 (8%) died within 100 days.

Conclusion: These findings suggest that normal gait, albumin and d-dimer levels are the most parsimonious way of identifying low risk ED patients.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cause of Death
  • Critical Illness / mortality*
  • Denmark
  • Emergency Service, Hospital / statistics & numerical data*
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis*
  • Gait*
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • Risk Assessment
  • Serum Albumin, Human / analysis*
  • Time Factors

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D
  • Serum Albumin, Human