Abstract
Eight amide compounds were obtained by condensation of appriopriate acid chlorides with homotryptamine and its 5-methoxyderivative. The effects of these compounds on the central nervous system were tested. m-Nitrobenzoylhomotryptamine showed the strongest sedative, anticonvulsive and analgesic properties.
MeSH terms
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5-Hydroxytryptophan / pharmacology
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Analgesics
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Animals
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Anticonvulsants / pharmacology
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Behavior, Animal / drug effects
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Chemical Phenomena
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Chemistry
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Lethal Dose 50
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Male
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Mice
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Motor Activity / drug effects
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Rats
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Sleep / drug effects
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Tryptamines / chemical synthesis*
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Tryptamines / pharmacology
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Tryptamines / toxicity
Substances
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Analgesics
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Anticonvulsants
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Tryptamines
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5-Hydroxytryptophan