Abstract
Herein, we describe a new strategy to prepare chalcogen-functionalized isoxazolines. The strategy involves the reaction of β,γ-unsaturated oximes with electrophilic selenium and tellurium species, affording 19 new selenium- and tellurium-containing isoxazolines in good yields after 1 h at room temperature. The method was efficiently extended to the synthesis of 5 new (bis)isoxazoline ditellurides. One of the prepared compounds, 3-phenyl-5-((phenylselanyl)methyl)-isoxazoline, demonstrated better anti-inflammatory and antiedematogenic effects than the reference drug Celecoxib.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Croton Oil
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Dose-Response Relationship, Drug
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Ear
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Edema / chemically induced
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Edema / drug therapy*
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Isoxazoles / chemical synthesis
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Isoxazoles / chemistry
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Isoxazoles / therapeutic use*
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Male
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Mice
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Molecular Structure
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Oximes / chemistry
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Oximes / therapeutic use*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Isoxazoles
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Oximes
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Croton Oil