Transcriptomics Identify a Unique Intermittent Hypoxia-mediated Profile in Obstructive Sleep Apnea

Am J Respir Crit Care Med. 2020 Jan 15;201(2):247-250. doi: 10.1164/rccm.201904-0832LE.

Authors

Chris D Turnbull^{1

2}, Lennard Y W Lee³, Thomas Starkey³, Dushendree Sen¹, John Stradling^{1

2}, Nayia Petousi^{1

2}

Affiliations

¹ Oxford University Hospitals NHS Foundation TrustOxford, United Kingdom.
² NIHR Biomedical Research Centre University of OxfordOxford, United Kingdomand.
³ Institute of Cancer and Genomic Sciences University of BirminghamBirmingham, United Kingdom.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Continuous Positive Airway Pressure
Gene Expression Profiling
Humans
Hypoxia / genetics*
Hypoxia / therapy
Inflammation / genetics
Interferon-alpha / genetics
Interferon-gamma / genetics
Leukocytes / metabolism
NF-kappa B / genetics
Oxygen Inhalation Therapy
Sequence Analysis, RNA
Signal Transduction
Sleep Apnea, Obstructive / genetics*
Sleep Apnea, Obstructive / therapy
Transcriptome
Transforming Growth Factor beta / genetics
Up-Regulation

Substances

Interferon-alpha
NF-kappa B
Transforming Growth Factor beta
Interferon-gamma