Abstract
Tumour necrosis factor was originally thought to kill tumour cells but not normal cells and to be a principal mediator in macrophage-mediated killing of tumour cells. It is now known to have a broad spectrum of additional activity ranging from regulatory effects on normal cells to inhibitory effects on viruses and parasites.
MeSH terms
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Animals
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Gene Expression Regulation / drug effects
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Humans
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Interferon-gamma / pharmacology
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Macrophages / drug effects
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Macrophages / physiology
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Mice
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Neoplasms / blood
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Neoplasms, Experimental / drug therapy
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Parasitic Diseases / blood
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Rabbits
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Recombinant Proteins / pharmacology
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T-Lymphocytes / drug effects
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Tumor Necrosis Factor-alpha* / biosynthesis
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Tumor Necrosis Factor-alpha* / pharmacology
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Tumor Necrosis Factor-alpha* / physiology
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Tumor Necrosis Factor-alpha* / therapeutic use
Substances
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Recombinant Proteins
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Tumor Necrosis Factor-alpha
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Interferon-gamma