Block anesthesia for the maxillary division (V2) of the trigeminal nerve is a suitable approach when an entire quadrant of teeth and/or associated structures are involved. The most effective approach to anesthetize the maxillary branch is intraorally via the greater palatine canal. This case report describes the use of a computer-aided design/computer-assisted manufacturing (CAD/CAM) implant surgical template designed with a guide channel to allow for the administration of maxillary nerve block through the greater palatine canal.