Bhlhe40 Keeps Resident T Cells Too Fit to Quit

Simone L Park; Laura K Mackay

doi:10.1016/j.immuni.2019.08.016

Bhlhe40 Keeps Resident T Cells Too Fit to Quit

Immunity. 2019 Sep 17;51(3):418-420. doi: 10.1016/j.immuni.2019.08.016.

Authors

Simone L Park¹, Laura K Mackay²

Affiliations

¹ Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
² Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia. Electronic address: [email protected].

PMID: 31533052
DOI: 10.1016/j.immuni.2019.08.016

Abstract

Factors regulating the differentiation of tissue-resident memory T (T_RM) cells and tumor-infiltrating lymphocytes (TILs) are incompletely understood. In this issue of Immunity, Li et al. identify Bhlhe40 as a transcriptional regulator of CD8⁺ T_RM cell and TIL persistence and activity by orchestrating metabolic and epigenetic programming.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes
Immunologic Memory*
Lymphocytes, Tumor-Infiltrating
Social Control, Formal
Transcription Factors*

Substances

Transcription Factors