Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study

Clin Infect Dis. 2020 Aug 14;71(4):1089-1091. doi: 10.1093/cid/ciz904.

Abstract

In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day 28 mortality than others (80% vs 12%; P = .011).

Keywords: H1N1 subtype; adult; influenza A virus; oseltamivir; pneumonia; respiratory distress syndrome; viral.

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use
  • Cohort Studies
  • Drug Resistance, Viral
  • Humans
  • Influenza A Virus, H1N1 Subtype* / genetics
  • Influenza, Human* / drug therapy
  • Neuraminidase / genetics
  • Oseltamivir / therapeutic use
  • Pneumonia* / drug therapy
  • Respiratory Distress Syndrome* / drug therapy

Substances

  • Antiviral Agents
  • Oseltamivir
  • Neuraminidase