How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing

Junbing Zhang; Liron Bar-Peled

doi:10.1016/j.chembiol.2019.09.001

How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing

Cell Chem Biol. 2019 Sep 19;26(9):1195-1196. doi: 10.1016/j.chembiol.2019.09.001.

Authors

Junbing Zhang¹, Liron Bar-Peled²

Affiliations

¹ Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
² Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].

PMID: 31539502
DOI: 10.1016/j.chembiol.2019.09.001

Abstract

In this issue of Cell Chemical Biology, Kang et al. (2019) describe the use of a high-throughput cell-based screen to identify chemical scaffolds that selectively inhibit mTORC1 nutrient sensing. Chemical proteomic-based target identification reveals class I glucose transporters as direct targets for these inhibitors, linking glucose sensing with mTORC1 regulation.

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MeSH terms

Glucose
Glucose Transport Proteins, Facilitative*
Mechanistic Target of Rapamycin Complex 1
Multiprotein Complexes
Proteomics
TOR Serine-Threonine Kinases*

Substances

Glucose Transport Proteins, Facilitative
Multiprotein Complexes
Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases
Glucose