Polymorphic DNA markers linked to cystic fibrosis locus in 20 Italian nuclear families

Gene Geogr. 1987 Dec;1(3):193-9.

Abstract

We report the haplotype characterization of 20 cystic fibrosis (CF) families for the allelic systems MET-H, D7S16, D7S13 and D7S8. Linkage disequilibrium between MET-H and CF was found in the population investigated. Twelve of the examined families were fully informative, 6 partially informative and 2 completely uninformative.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Chromosome Mapping
  • Cystic Fibrosis / diagnosis*
  • Cystic Fibrosis / genetics
  • DNA / analysis*
  • Gene Frequency*
  • Genetic Linkage
  • Genetic Markers
  • Haplotypes*
  • Humans
  • Italy
  • Nuclear Family
  • Phenotype
  • Polymorphism, Genetic*
  • Prenatal Diagnosis

Substances

  • Genetic Markers
  • DNA