1. With CsA treatment there has been an increase in procurement of older kidneys and transplantation of older recipients. 2. Recipient age shows a 5% difference in graft survival between the best and the worst. In contrast, donor age shows a 16% difference in graft survival. 3. Female donor kidneys have a poor prognosis that is not completely associated with early function. This may indicate increasing dysfunction between one month and one year. 4. The drop in serum creatinine levels is directly proportional to recipient age. In zero- to 10-year-old recipients the rapid serum creatinine drop may be due to the transplantation of a normal size kidney into a small recipient. 5. Matching is strongly indicated for recipients receiving kidneys from young or old donors. 6. Transfusion is indicated for all groups and particularly for young donors and recipients. 7. Ten-year functional graft survival indicates decreasing immunocompetence with increasing recipient age. Ten-year graft survival with different aged donors indicates high risk with young and old donors.