Abstract
The photophysical properties of a new series of fluorenyl porphyrins bearing water-solubilising oligoethyleneglycol chains are described. These biocompatible compounds present very good two-photon absorption and singlet oxygen generation properties, while retaining some fluorescence in water. After testing in vitro on breast cancer cells, some of them were shown to be efficient non-toxic two-photon photosensitisers allowing for fluorescence imaging, thus demonstrating their theranostic potential.
MeSH terms
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Biocompatible Materials / chemistry
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Cell Membrane Permeability
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Cell Survival / drug effects
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Fluorenes / chemistry*
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Humans
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Infrared Rays
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MCF-7 Cells
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Microscopy, Fluorescence, Multiphoton / methods
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Molecular Structure
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Optical Imaging / methods
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Photochemotherapy / methods*
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Photosensitizing Agents / chemistry*
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Polyethylene Glycols / chemistry
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Porphyrins / chemistry*
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Singlet Oxygen / chemistry
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Structure-Activity Relationship
Substances
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Biocompatible Materials
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Fluorenes
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Photosensitizing Agents
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Porphyrins
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Singlet Oxygen
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Polyethylene Glycols