Heterotopic ossification: radiological and pathological review

Radiol Oncol. 2019 Sep 24;53(3):275-284. doi: 10.2478/raon-2019-0039.

Abstract

Background Heterotopic Ossification (HO) is a common condition referring to ectopic bone formation in soft tissues. It has two major etiologies, acquired (more common) and genetic. The acquired form is closely related to tissue trauma. The exact pathogenesis of this disease remains unclear; however, there is ongoing research in prophylactic and therapeutic treatments that is promising. Conclusions Due to HO potential to cause disability, it is so important to differentiate it from other causes in order to establish the best possible management.

Keywords: heterotopic ossification; pathology; radiology.

Publication types

  • Review

MeSH terms

  • Calcinosis / diagnostic imaging
  • Chondrocalcinosis / diagnostic imaging
  • Diagnosis, Differential
  • Fractures, Avulsion / diagnostic imaging
  • Gout / diagnostic imaging
  • Humans
  • Magnetic Resonance Imaging
  • Myositis Ossificans / diagnostic imaging
  • Ossification, Heterotopic / diagnostic imaging*
  • Ossification, Heterotopic / etiology
  • Ossification, Heterotopic / therapy
  • Osteosarcoma / diagnostic imaging
  • Radiography
  • Tendinopathy / diagnostic imaging
  • Wounds and Injuries / complications