Whole-exome sequencing reveals the subclonal expression of NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia

Pediatr Blood Cancer. 2020 Jan;67(1):e28019. doi: 10.1002/pbc.28019. Epub 2019 Sep 25.

Authors

Yoshinori Tsurusaki^{1

2}, Jun-Ichi Nagai³, Sachio Fujita⁴, Masanaka Sugiyama⁴, Wataru Nakamura⁴, Akiko Hayashi⁴, Naoyuki Miyagawa⁴, Dai Keino⁴, Tomoko Yokosuka⁴, Fuminori Iwasaki⁴, Satoshi Hamanoue⁴, Masae Shiomi⁴, Shoko Goto⁴, Kenji Kurosawa⁵, Hiroaki Goto⁴

Affiliations

¹ Clinical Research Institute, Kanagawa Children's Medical Center, Yokohama, Japan.
² Faculty of Nutritional Science, Sagami Women's University, Sagamihara, Japan.
³ Department of Clinical Laboratory, Kanagawa Children's Medical Center, Yokohama, Japan.
⁴ Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
⁵ Division of Medical Genetics, Kanagawa Children's Medical Center, Yokohama, Japan.

PMID: 31556219
DOI: 10.1002/pbc.28019

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Antineoplastic Agents / therapeutic use
Child
Dasatinib / therapeutic use
Exome Sequencing / methods*
Humans
Male
Oncogene Proteins, Fusion / genetics*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
Prognosis

Substances

Antineoplastic Agents
NUP214-ABL1 fusion protein, human
Oncogene Proteins, Fusion
Dasatinib